Friday, January 23, 2009

Can you avoid exposure to cold and flu germs? What preventative measures really help? Such a simple question prompts a very complicated answer from science -- mostly because it's not clear how the viruses travel from one person to the next. One paper I read while researching my two-part story for the Los Angeles Times was entitled: "Rhinovirus transmission: One if by air, two if by hand."

In another story for the Los Angeles Times, I wrote about some rare but serious side effects linked to the osteoporosis drug, Fosamax.

For Nature (subscription only), I profiled a scientist who studies AIDS vaccines in animal models. Dan Barouch was in the midst of a three-year long study in monkeys when an important human vaccine trial was called off because it wasn't working. Barouch's vaccine was of a similar type (based on an adenovirus), but his method was different enough that he stuck with his experiment -- to a positive end. While much remains to be learned about vaccinating against HIV, this work shows that the regimen is as important as the vaccine itself.

Tuesday, December 23, 2008

Eating fish is good for you and bad for you at the same time. Omega-3 fatty acids are brain food for fetuses, babies and children, and they promote cardiovascular health in adults. But fish also are contaminated with mercury, a toxin which interferes with the development of the nervous system in those same fetuses and babies. I wrote about the science behind a controversy brewing between two federal agencies that regulate fish for consumption -- the FDA and the EPA -- in a two-part article for the Los Angeles Times.

After carbon dioxide, methane is the second biggest contributor to the greenhouse gases involved in global warming. A new natural source of methane was identified by a monitoring station in Greenland during freeze-up in the fall of 2007. Results were published in Nature earlier this month and I interviewed the lead author, Torbin Christensen of Sweden, about the story behind the story (subscription only) for Nature's Authors Page.

Friday, December 19, 2008

I wrote about the movement towards broader testing for HIV for the Los Angeles Times. In the past, the test was only offered to people in high-risk groups, such as i.v. drug users and gay men. Now, everyone between the ages of 13 and 65 should be screened, says the Center for Disease Control and Prevention. Age 13, you say? So did I, as the mom of a 12-year-old. Think of it as a necessary education in today's world. AIDS isn't going away soon, and as teens contemplate their sexuality and parents do their best to talk to their teens, a doctor saying, let's test for cholesterol and HIV, will drive that point home.

For the Author's Page at Nature (subscription only), I profiled Barry Trost, a medicinal chemist who found a shortcut to a complex chemical structure -- one that may pave the way for new anti-tumor drugs. Trost believes chemistry and development of synthetic tools is the key to improving the quality and the diversity of leads pursued by the pharmaceutical industry.
Can people be vaccinated against high blood pressure? I wrote about two companies that think it's a viable therapy for Nature Biotechnology (subscription only). The vaccine stimulates the body to make antibodies against angiotensin -- a circulating hormone that tightens blood vessels -- and the target of most current antihypertensive medications. Early results in small studies have shown the vaccine to be safe and to have some efficacy. However, the products are up against two hurdles: showing they work better than standard treatments and overcoming physician skittishness about biologic products (as opposed to traditional pharmaceuticals).

One group of doctors who are very comfortable with biologics are rheumatologists. A biologic drug that has offered real hope for people suffering rheumatoid arthritis is infliximab (Remicade®), which is an antibody against an inflammatory mediator called tumor necrosis factor or TNF. I covered the Janssen Award symposium for the New York Academy of Sciences (subscription only) honoring the drug's inventors, Marc Feldmann and Ravinder Maini of Imperial College London. Their first success was reported in 1993 in a small study of 20 patients, whom Maini described described as “train wrecks—severely disabled people who had been through the gamut of therapies with no hope of benefit.”

Saturday, November 22, 2008

Is one city really "healthier" than another? After Burlington VT made news by being called the healthiest city in the US, I explored city rankings in general, and the basis for Burlington's honor specifically, for the LA Times . Another thing? All the cities in a top ten list are likely to be equivalent -- in other words, #10 (and maybe even #25) is not measurably different from #1.

Two weeks ago, I looked into the issue of drinking during pregnancy for the LA Times. No one disputes the damaging effects on the baby, called fetal alcohol syndrome, when a pregnant mom drinks a lot. What's not known is where the threshold lies between total abstinence and dangerous drunkenness. A recent study may help doctors reassure women who imbibe every once in a while, and have that reassurance be based on scientific evidence.

Thursday, October 30, 2008

I explored a rather grim topic for the LA Times Health section -- whether suicide might increase as the economy falls. Two recent deaths in Los Angeles were seemingly triggered by large financial losses (in one case) and home foreclosure (in the other). In fact, people rarely, if ever, commit suicide over one bad event. Studies have shown that some 90% of suicides occur in people with mental disorders (which makes them preventable by treating mental illness).

I told a scientist's story on the Nature (subscription only). While studying a factor involved in immunity, Peter Creswell discovered one pathogen -- food-borne Listeria -- that turns the factor into a traitor, benefitting bug over host.

For Skidmore's alumni magazine, I found out why seven alums work in the same office at NYU Langone Medical Center. One of them, boss Andrew Rubin, has found Skidmore grads to be his best source of motivated, ambitious employees. By recruiting at Skidmore, Rubin has also found a way to give back to his alma mater.

Wednesday, October 15, 2008

My LA Times article this week considered the science behind the claim that energy drinks, packed with caffeine, sugar, and supposedly active botanicals, might lead to substance abuse. The so-called gateway hypothesis says that certain "soft" drugs such as marijuana or alcohol are stepping stones to using harder and more addictive drugs. Energy drinks, such as Red Bull, Wired, Boo-Koo, and Fixx, have been linked to drinking more booze and to abusing prescription stimulants such as Ritalin.

I also have a short article in Parenting magazine about finding math in everyday children's activities, everything from playing tea party and building block towers to singing the ABC’s and putting away toys. Most of us think of math as counting and addition tables -- what educators call "math facts" -- but that’s not all it is. Concepts such as sequencing, categorizing, and patterns lay the groundwork for much of the math that kids will encounter in school.